Macrobacteria are enormous, macroscopic bacteria. They come in billions of varieties, although in most varieties they are pickle-shaped with a single, long flagella used for movement and offensive purposes in certain scenarios. They survive off of pure instinct, although their intelligence is several magnitudes higher than their microscopic counterparts.

They are hunted naturally by Macoviruses, although some sapient beings in the Prime Material Plane have been known to kill and even consume the matter of Macrobacteria.